Abstract
Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death.
| Original language | English |
|---|---|
| Pages (from-to) | 313-318 |
| Number of pages | 6 |
| Journal | Human Psychopharmacology : Clinical and Experimental |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jul 2016 |
Keywords
- alcohol
- antipsychotic agents
- drug therapy combination
- QT prolongation
- risk factors
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Carrà, G., Crocamo, C., Bartoli, F., Lax, A., Tremolada, M., Lucii, C., Martinotti, G., Nosè, M., Bighelli, I., Ostuzzi, G., Castellazzi, M., Clerici, M., Barbui, C., Acciavatti, T., Adamo, A., Aguglia, A., Albanese, C., Baccaglini, S., Bardicchia, F., ... Zanobini, V. (2016). First-generation antipsychotics and QTc: any role for mediating variables? Human Psychopharmacology : Clinical and Experimental, 31(4), 313-318. https://doi.org/10.1002/hup.2540
Carrà, Giuseppe ; Crocamo, Cristina ; Bartoli, Francesco et al. / First-generation antipsychotics and QTc : any role for mediating variables?. In: Human Psychopharmacology : Clinical and Experimental. 2016 ; Vol. 31, No. 4. pp. 313-318.
@article{bb96485aff4c4d269328befc6e1d61f8,
title = "First-generation antipsychotics and QTc: any role for mediating variables?",
abstract = "Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death.",
keywords = "alcohol, antipsychotic agents, drug therapy combination, QT prolongation, risk factors",
author = "Giuseppe Carr{\`a} and Cristina Crocamo and Francesco Bartoli and Annamaria Lax and Martina Tremolada and Claudio Lucii and Giovanni Martinotti and Michela Nos{\`e} and Irene Bighelli and Giovanni Ostuzzi and Mariasole Castellazzi and Massimo Clerici and Corrado Barbui and T. Acciavatti and A. Adamo and A. Aguglia and C. Albanese and S. Baccaglini and F. Bardicchia and R. Barone and Y. Barone and C. Bergamini and F. Bertolini and S. Bolognesi and A. Bordone and P. Bortolaso and M. Bugliani and C. Calandra and S. Cal{\`o} and G. Cardamone and M. Caroleo and E. Carra and D. Carretta and L. Chiocchi and E. Cinosi and M. Corbo and E. Corsi and R. Costanzo and G. Costoloni and F. D{\textquoteright}Arienzo and S. Debolini and {De Capua}, A. and {Di Napoli}, {W. A.} and M. Dinelli and E. Facchi and F. Fargnoli and F. Fiori and A. Franchi and F. Gardellin and C. Gastaldon and E. Gazzoletti and L. Ghio and M. Giacomin and M. Gregis and N. Iovieno and D. Koukouna and C. Lintas and A. Luca and M. Luca and M. Lussetti and M. Madrucci and N. Magnani and L. Magni and E. Manca and C. Martorelli and R. Mattafirri and C. Paladini and D. Papola and M. Percudani and G. Perini and P. Petrosemolo and M. Pezzullo and S. Piantanida and F. Pinna and K. Prato and D. Prestia and D. Quattrone and C. Reggianini and F. Restaino and M. Ribolsi and G. Rinosi and C. Rizzo and R. Rizzo and M. Roggi and G. Rossi and S. Rossi and S. Ruberto and M. Santi and R. Santoro and G. Sepede and Signorelli, {M. S.} and F. Soscia and F. Sozzi and P. Staffa and M. Stilo and S. Strizzolo and F. Suraniti and N. Tavian and L. Tortelli and F. Tosoni and M. Valdagno and V. Zanobini",
year = "2016",
month = jul,
day = "1",
doi = "10.1002/hup.2540",
language = "English",
volume = "31",
pages = "313--318",
journal = "Human Psychopharmacology : Clinical and Experimental",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",
number = "4",
}
Carrà, G, Crocamo, C, Bartoli, F, Lax, A, Tremolada, M, Lucii, C, Martinotti, G, Nosè, M, Bighelli, I, Ostuzzi, G, Castellazzi, M, Clerici, M, Barbui, C, Acciavatti, T, Adamo, A, Aguglia, A, Albanese, C, Baccaglini, S, Bardicchia, F, Barone, R, Barone, Y, Bergamini, C, Bertolini, F, Bolognesi, S, Bordone, A, Bortolaso, P, Bugliani, M, Calandra, C, Calò, S, Cardamone, G, Caroleo, M, Carra, E, Carretta, D, Chiocchi, L, Cinosi, E, Corbo, M, Corsi, E, Costanzo, R, Costoloni, G, D’Arienzo, F, Debolini, S, De Capua, A, Di Napoli, WA, Dinelli, M, Facchi, E, Fargnoli, F, Fiori, F, Franchi, A, Gardellin, F, Gastaldon, C, Gazzoletti, E, Ghio, L, Giacomin, M, Gregis, M, Iovieno, N, Koukouna, D, Lintas, C, Luca, A, Luca, M, Lussetti, M, Madrucci, M, Magnani, N, Magni, L, Manca, E, Martorelli, C, Mattafirri, R, Paladini, C, Papola, D, Percudani, M, Perini, G, Petrosemolo, P, Pezzullo, M, Piantanida, S, Pinna, F, Prato, K, Prestia, D, Quattrone, D, Reggianini, C, Restaino, F, Ribolsi, M, Rinosi, G, Rizzo, C, Rizzo, R, Roggi, M, Rossi, G, Rossi, S, Ruberto, S, Santi, M, Santoro, R, Sepede, G, Signorelli, MS, Soscia, F, Sozzi, F, Staffa, P, Stilo, M, Strizzolo, S, Suraniti, F, Tavian, N, Tortelli, L, Tosoni, F, Valdagno, M & Zanobini, V 2016, 'First-generation antipsychotics and QTc: any role for mediating variables?', Human Psychopharmacology : Clinical and Experimental, vol. 31, no. 4, pp. 313-318. https://doi.org/10.1002/hup.2540
First-generation antipsychotics and QTc: any role for mediating variables? / Carrà, Giuseppe; Crocamo, Cristina; Bartoli, Francesco et al.
In: Human Psychopharmacology : Clinical and Experimental, Vol. 31, No. 4, 01.07.2016, p. 313-318.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - First-generation antipsychotics and QTc
T2 - any role for mediating variables?
AU - Carrà, Giuseppe
AU - Crocamo, Cristina
AU - Bartoli, Francesco
AU - Lax, Annamaria
AU - Tremolada, Martina
AU - Lucii, Claudio
AU - Martinotti, Giovanni
AU - Nosè, Michela
AU - Bighelli, Irene
AU - Ostuzzi, Giovanni
AU - Castellazzi, Mariasole
AU - Clerici, Massimo
AU - Barbui, Corrado
AU - Acciavatti, T.
AU - Adamo, A.
AU - Aguglia, A.
AU - Albanese, C.
AU - Baccaglini, S.
AU - Bardicchia, F.
AU - Barone, R.
AU - Barone, Y.
AU - Bergamini, C.
AU - Bertolini, F.
AU - Bolognesi, S.
AU - Bordone, A.
AU - Bortolaso, P.
AU - Bugliani, M.
AU - Calandra, C.
AU - Calò, S.
AU - Cardamone, G.
AU - Caroleo, M.
AU - Carra, E.
AU - Carretta, D.
AU - Chiocchi, L.
AU - Cinosi, E.
AU - Corbo, M.
AU - Corsi, E.
AU - Costanzo, R.
AU - Costoloni, G.
AU - D’Arienzo, F.
AU - Debolini, S.
AU - De Capua, A.
AU - Di Napoli, W. A.
AU - Dinelli, M.
AU - Facchi, E.
AU - Fargnoli, F.
AU - Fiori, F.
AU - Franchi, A.
AU - Gardellin, F.
AU - Gastaldon, C.
AU - Gazzoletti, E.
AU - Ghio, L.
AU - Giacomin, M.
AU - Gregis, M.
AU - Iovieno, N.
AU - Koukouna, D.
AU - Lintas, C.
AU - Luca, A.
AU - Luca, M.
AU - Lussetti, M.
AU - Madrucci, M.
AU - Magnani, N.
AU - Magni, L.
AU - Manca, E.
AU - Martorelli, C.
AU - Mattafirri, R.
AU - Paladini, C.
AU - Papola, D.
AU - Percudani, M.
AU - Perini, G.
AU - Petrosemolo, P.
AU - Pezzullo, M.
AU - Piantanida, S.
AU - Pinna, F.
AU - Prato, K.
AU - Prestia, D.
AU - Quattrone, D.
AU - Reggianini, C.
AU - Restaino, F.
AU - Ribolsi, M.
AU - Rinosi, G.
AU - Rizzo, C.
AU - Rizzo, R.
AU - Roggi, M.
AU - Rossi, G.
AU - Rossi, S.
AU - Ruberto, S.
AU - Santi, M.
AU - Santoro, R.
AU - Sepede, G.
AU - Signorelli, M. S.
AU - Soscia, F.
AU - Sozzi, F.
AU - Staffa, P.
AU - Stilo, M.
AU - Strizzolo, S.
AU - Suraniti, F.
AU - Tavian, N.
AU - Tortelli, L.
AU - Tosoni, F.
AU - Valdagno, M.
AU - Zanobini, V.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death.
AB - Objective: Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid conditions, such as co-occurring alcohol abuse/dependence. We aimed to study potential mediating roles of different, related, candidate variables on QTc. Methods: We capitalized on data from a large (N = 2366), cross-sectional, national survey, the STAR Network QTc study, using a representative sample of people taking FGAs, and recruited from mental health services across Italy. Results: About one-third of the sample was treated with FGAs, and almost one-tenth of the subjects took a different, additional, drug known to cause QTc prolongation. Our findings confirmed that there is an impact from FGAs, age, gender, alcohol misuse, and concurrent risky drugs on QTc. However, comorbid alcohol abuse/dependence and concurrent risky drugs did not mediate the effect of FGAs on QTc. Conclusions: Our findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death.
KW - alcohol
KW - antipsychotic agents
KW - drug therapy combination
KW - QT prolongation
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=84978152172&partnerID=8YFLogxK
U2 - 10.1002/hup.2540
DO - 10.1002/hup.2540
M3 - Article
C2 - 27245736
AN - SCOPUS:84978152172
SN - 0885-6222
VL - 31
SP - 313
EP - 318
JO - Human Psychopharmacology : Clinical and Experimental
JF - Human Psychopharmacology : Clinical and Experimental
IS - 4
ER -
Carrà G, Crocamo C, Bartoli F, Lax A, Tremolada M, Lucii C et al. First-generation antipsychotics and QTc: any role for mediating variables? Human Psychopharmacology : Clinical and Experimental. 2016 Jul 1;31(4):313-318. doi: 10.1002/hup.2540
